Lay Press

Publications

Chen D, Fan Z, Rauh M, Buchfelder M, Eyupoglu IY, Savaskan N. ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner. Oncogene. 2017 Oct 5;36(40):5593-5608. doi: 10.1038/onc.2017.146. http://www.nature.com/articles/onc2017146

http://rdcu.be/s5h8

Chen D, Rauh M, Buchfelder M, Eyupoglu IY, Savaskan N. The oxido-metabolic driver ATF4 enhances temozolamide chemo-resistance in human gliomas. Oncotarget. 2017; 8(31):51164-51176. doi: 10.18632/oncotarget.17737

Dahlmanns M, Yakubov E, Chen D, Sehm T, Rauh M, Savaskan N, Wrosch JK. Chemotherapeutic xCT inhibitors sorafenib and erastin unraveled with the synaptic optogenetic function analysis tool. Cell Death Discov. 2017; 3:17030. doi: 10.1038/cddiscovery.2017.30

Ackermann A, Karagöz AÇ, Ghoochani A, Buchfelder M, Eyüpoglu I, Tsogoeva SB, Savaskan N. Cytotoxic profiling of artesunic and betulinic acids and their synthetic hybrid compound on neurons and gliomas. Oncotarget. 2017 Jun 7;8(37):61457-61474. doi: 10.18632/oncotarget.18390. eCollection 2017 Sep 22.

Chen D, Rauh M, Buchfelder M, Eyupoglu IY, Savaskan N. The oxido-metabolic driver ATF4 enhances temozolamide chemo-resistance in human gliomas. Oncotarget. 2017 May 9;8(31):51164-51176. doi: 10.18632/oncotarget.17737. eCollection 2017 Aug 1.

Fan Z, Wirth AK, Chen D, Wruck CJ, Rauh M, Buchfelder M, Savaskan N. Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis. Oncogenesis. 2017 Aug 14;6(8):e371. doi: 10.1038/oncsis.2017.65.

Chen D, Eyupoglu IY, Savaskan N. Ferroptosis and Cell Death Analysis by Flow Cytometry. Methods Mol Biol. 2017;1601:71-77. doi: 10.1007/978-1-4939-6960-9_6.

Ghoochani A, Hatipoglu Majernik G, Sehm T, Wach S, Buchfelder M, Taubert H, Eyupoglu IY, Savaskan N. Cabazitaxel operates anti-metastatic and cytotoxic via apoptosis induction and stalls brain tumor angiogenesis. Oncotarget. 2016 Jun 21;7(25):38306-38318. doi: 10.18632/oncotarget.9439.

Schnell L, Ghoochani A, Mateos JM, Buchfelder M, Wiendieck K, Schäfer MK, Eyupoglu IY, Savaskan NE. Plasticity Related Gene 3 (PRG3) overcomes myelin-associated growth inhibition and promotes functional recovery after spinal cord injury. Aging (Albany NY). 2016 Oct 15;8(10):2463-2487. doi: 10.18632/aging.101066.

Sehm T, Rauh M, Wiendieck K, Buchfelder M, Eyüpoglu IY, Savaskan NE. Temozolomide toxicity operates in a xCT/SLC7a11 dependent manner and is fostered by ferroptosis. Oncotarget. 2016 Nov 15;7(46):74630-74647. doi: 10.18632/oncotarget.11858.

Ghoochani A, Schwarz MA, Yakubov E, Engelhorn T, Doerfler A, Buchfelder M, Bucala R, Savaskan NE, Eyüpoglu IY. MIF-CD74 signaling impedes microglial M1 polarization and facilitates brain tumorigenesis. Oncogene. 2016 Dec 1;35(48):6246-6261. doi: 10.1038/onc.2016.160. Epub 2016 May 9.

Fan Z, Bittermann-Rummel P, Yakubov E, Chen D, Sehm T, Hatipoglu Majernik G, Hock SW, Schwarz M, Engelhorn T, Doerfler A, Buchfelder M, Eyupoglu IY, Savaskan NE. PRG3 induces Ras-dependent oncogenic cooperation in gliomas. Oncotarget. 2016 May 3;7(18):26692-708. doi: 10.18632/oncotarget.8592.

Proske J, Walter L, Bumes E, Hutterer M, Vollmann-Zwerenz A, Eyüpoglu IY, Savaskan NE, Seliger C, Hau P, Uhl M. Anticancer Res. 2016 Mar;36(3):899-905. Adaptive Immune Response to and Survival Effect of Temozolomide- and Valproic Acid-induced Autophagy in Glioblastoma.

Xu T, Fan Z, Li W, Dietel B, Wu Y, Beckmann MW, Wrosch JK, Buchfelder M, Eyupoglu IY, Cao Z, Savaskan NE. Identification of two novel Chlorotoxin derivatives CA4 and CTX-23 with chemotherapeutic and anti-angiogenic potential. Sci Rep. 2016 Feb 2;6:19799. doi: 10.1038/srep19799.

Eyüpoglu IY, Savaskan NE. Epigenetics in Brain Tumors: HDACs Take Center Stage. Curr Neuropharmacol. 2016;14(1):48-54.

Ghoochani A, Yakubov E, Sehm T, Fan Z, Buchfelder M, Eyupoglu IY, Savaskan NE,. VOGiM: a versatile ex vivo technique for analyzing tumor angiogenesis and microglia. Oncotarget. 2015; doi: 10.18632/oncotarget.6550. [Epub ahead of print].

Savaskan NE, Fan Z, Buchfelder M, Eyupoglu IY. Neurodegeneration in the Brain Tumor Microenvironment: Glutamate in the Limelight. Curr Neuropharmacol. 2015;13(2):258-65.

Friedlein K, Bozhkov Y, Hore N, Merkel A, Sommer B, Brandner S, Buchfelder M, Savaskan NE*, Eyüpoglu IY. A new functional classification system (FGA/B) with prognostic value for glioma patients. Sci Rep. 2015 Jul 21;5:12373. doi: 10.1038/srep12373.

Eyüpoglu IY, Hore N, Buslei R, Fan Z, Merkel A, Buchfelder M, Savaskan NE. Intraoperative vascular DIVA (vDiVA) surgery reveals angiogenic hotspots in tumor zones of malignant gliomas. Sci Rep. 2015 Jan 22;5:7958. doi: 10.1038/srep07958.

Hatipoglu G, Hock SW, Weiss R, Fan Z, Sehm T, Ghoochani A, Buchfelder M, Savaskan NE*, Eyüpoglu IY. Sunitinib impedes brain tumor progression and reduces tumor-induced neurodegeneration in the microenvironment. Cancer Sci. 2015. doi: 10.1111/cas.12580.

Wolf I, Fan Z., Rauh M, Seufert S, Hore N, Buchfelder M, Savaskan NE*, Eyüpoglu IY,. Histone deacetylases inhibition by SAHA/Vorinostat normalizes the glioma microenvironment via xCT equilibration. Sci Rep. 2014 Sep 17;4:6226. doi: 10.1038/srep06226.

Yakubov E, Buchfelder M, Eyüpoglu IY, Savaskan NE. Selenium Action in Neuro-Oncology. Biol Trace Elem Res. 2014. [Epub ahead of print]

Sehm T; Fan Z.; Weiss R, Schwarz M, Engelhorn T, Hore N, Doerfler A, Buchfelder M, Eyüpoglu IY, Savaskan NE. The impact of dietary isoflavonoids on malignant brain tumors. CANCER MEDICINE 2014; 3(4):865-877.

Fan Z, Sehm T, Rauh M, Buchfelder M, Eyüpoglu IY, Savaskan NE. Dexamethasone alleviates tumor-associated brain damage and angiogenesis. PONE 2014, 9(4):e93264.

Eyüpoglu IY, Buchfelder M, Savaskan NE. Surgical resection of malignant gliomas-role in optimizing patient outcome. Nat Rev Neurol. 2013; 9(3):141-51.

Savaskan NE, Fingerle-Rowson G, Buchfelder M, Eyüpoglu IY. Brain miffed by macrophage migration inhibitory factor. Int J Cell Biol. 2012; 2012:139573.

Choi J, Stradmann-Bellinghausen B, Yakubov E, Savaskan NE, Régnier-Vigouroux A. Glioblastoma cells induce differential glutamatergic gene expressions in human tumor-associated microglia/macrophages and monocyte-derived macrophages. Cancer Biol Ther. 2015 Aug 3;16(8):1205-13. doi: 10.1080/15384047.2015.1056406.

Eyüpoglu, N. Hore, N.E. Savaskan, P. Grummich, K. Roessler, M. Buchfelder, O. Ganslandt: Improving the Extent of Malignant Glioma Resection by Dual Intraoperative Visualization Approach. Plos One; September 2012, Vol 7 – online

Vogt J, Glumm R, Schlüter L, Schmitz D, Rost BR, Streu N, Rister B, Suman Bharathi B, Gagiannis D, Hildebrandt H, Weinhold B, Mühlenhoff M, Naumann T, Savaskan NE, Brauer AU, Reutter W, Heimrich B, Nitsch R, Horstkorte R. Homeostatic regulation of NCAM polysialylation is critical for correct synaptic targeting. Cell Mol Life Sci. 2011 Nov 9. [Epub ahead of print]

Savaskan NE, Seufert S, Hauke J, Tränkle C, Eyupoglu IY and Hahnen E. Dissection of Mitogenic and Neurodegenerative Actions of Cystine and Glutamate in Malignant Gliomas. Oncogene 2011, 30(1):43-53.

Savaskan NE and Eyupoglu IY. xCT modulation in gliomas: Relevance to energy metabolism and tumor microenvironment normalization. Ann Anat 2010, 192(5):309-13.

Halstead J, Savaskan NE*, van Horck F, Snell M, Jan Keune W, ten Klooster JP, Hordijk PL, Moolenaar WH, Divecha N. Rac controls the intracellular localisation of PIP5Kβ to regulate the synthesis of PtdIns(4,5)P2 which is required to induce focal adhesion dissambly and neurite retraction. J Cell Science 2010, 123(Pt 20):3535-46.

Nitsch R, Savaskan NE. Plasticity Related Gene 5 (PRG5) Induces Filopodia and Neurite Growth and Impedes LPA and Nogo-A Mediated Axonal Retraction. Mol Biol Cell. 2010, 21, 521 – 537.

Trimbuch T, Beed P, Vogt J, Schuchmann S, Maier N, Kintscher M, Breustedt J, Schuelke M, Streu N, Kieselmann O, Brunk I, Laube G, Strauss U, Battefeld A, Wende H, Birchmeier C, Wiese S, Sendtner M, Kawabe H, Kishimoto-Suga M, Brose N, Baumgart J, Geist B, Aoki J, Savaskan NE, Bräuer AU, Chun J, Ninnemann O, Schmitz D, Nitsch R. Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling. Cell. 2009; 138(6):1222-35.

Savaskan NE, Hahnen E, and Eyupoglu IY. The xC- Cystine/Glutamate Antiporter: A potential target for therapy of cancer and other diseases: Yet another cytotoxic anticancer approach? J Cell Physiol 2009, 220(2):531-532.

Engelhorn T, Savaskan NE*, Schwarz M, Kreutzer J, Hahnen E, Doerfler A, Ganslandt C, Nimsky C, Buchfelder M, and Eyupoglu IY. Cellular characterization of the peritumoral zone in iRNA mediated xCT silencing inhibits neurodegeneration and alleviates brain edema zone in malignant brain tumors. Cancer Science 2009, 100(10):1856-62.

Savaskan NE, Weinmann O, Heimrich B, and Eyüpoglu. High resolution neurochemical gold staining method for peripheral and central nervous system myelin at the light and electron microscopic level. Cell Tissue Res 2009, 337(2):213-21.

Savaskan NE, Hacke A, Hahnen E, Engelhorn T, Doerfler A, Ganslandt C, Nimsky C, Buchfelder M, and Eyupoglu IY. siRNA mediated xCT silencing inhibits neurodegeneration and alleviates brain edema in malignant gliomas. Nature Medicine 2008, 14 (6): 629-632. Considered as featured article in SciBX 2008 29 May 2008 • VOLUME 1 / NUMBER 18

Savaskan NE., Ufer C., Kuhn H., Borchert A. The molecular biology of GPx4. Biological Chemistry 2007; 388 (10): 1007-1017.

Savaskan NE., Borchert A, Brauer AU., Kuhn H. Role for glutathione peroxidase-4 in neuronal development and injury. Free Radical Biology & Medicine 2007; 43 (2): 191-201.

Savaskan NE, Rocha L, Kotter MR, Baer A, Lubec G, van Meeteren L, Kishi Y, Aoki J, Moolenaar WH, Nitsch R, Brauer AU. Autotaxin/lysophospholipase D (NPP2): evelopmental expression of the LPA-generating ectoenzyme in the brain. Cell Mol Life Sci. 2007; 64 (2): 230-43.

Zhang Y, Zhou Y, Schweizer U, Savaskan NE, Hua D, Kipnis J, Hatfield DL, Gladyshev VN. Comparative analysis of selenocysteine machinery and selenoproteome gene expression in mouse brain identifies neurons as key functional sites of selenium in mammals. J Biol Chem. 2008, 283(4):2427-38.

Hoppe B, Brauer A, Kuhlacher M, Savaskan NE, Behne D, Kyriakopoulos. Expression patterns of selenoproteins in brain cell lines and in brain regions of the rat. Cell Tissue Res. 2008, 332(3):403-14.

Dalla Puppa L, Savaskan NE, Brauer AU, Behne D, Kyriakopoulos A. The role of selenite on microglial migration. Ann N Y Acad Sci. 2007;1096:179-83.

Borchert A, Wang CC, Ufer C, Schiebel H, Savaskan NE, Kuhn H. The role of phospholipid hydroperoxide glutathione peroxidase isoforms in murine embryogenesis. J Biol Chem. 2006;281(28):19655-64.

Peeva GP, Angelova SK, Guntinas-Lichius O, Streppel M, Irintchev A, Schutz U, Popratiloff A, Savaskan NE, Brauer AU, Alvanou A, Nitsch R, Angelov DN Improved outcome of facial nerve repair in rats is associated with enhanced regenerative response of motoneurons and augmented neocortical plasticity. Eur J Neurosci. 2006;24(8):2152-62.

Eyupoglu IY, Hahnen E, Siebzehnrubl FA, Savaskan NE, Buslei R, Luders M, Trankle C, Wick W, Weller M, Fahlbusch R, Blumcke I. Suberoylanilide hydroxamic acid (SAHA) has potent anti-glioma properties in vitro, ex vivo and in vivo. Mol Cancer Therapeutics. 2006, 5(5):1248-55.

Schafer M, Brauer AU, Savaskan NE, Rathjen FG, Brummendorf T. Neurotractin/kilon promotes neurite outgrowth and is expressed on reactive astrocytes after entorhinal cortex lesion. Mol Cell Neurosci. 2005; 29(4):580-90.

Aktas O, Prozorovski T, Smorodchenko A, Savaskan NE, Lauster R, Kloetzel PM, Infante-Duarte C, Brocke S, Zipp F. Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis. J Immunol. 2004, 173(9):5794-800.

Bräuer AU, Savaskan NE, Plaschke M., Ninnemann O., Nitsch R. CCK expression in the brain Molecular evidence revealed by Differential Display RT-PCR. Neurosci. 2003, 121(1):111-21.

Borchert A, Savaskan NE, Kuhn H. Regulation of expression of the phospholipid hydroperoxide/sperm nucleus glutathione peroxidase gene. Tissue-specific expression pattern and identification of functional cis- and trans-regulatory elements. J Biol Chem. 2003; 278(4):2571-80.

Meier S, Brauer AU, Heimrich B, Nitsch R, Savaskan NE. Myelination in the hippocampus during development and following lesion. Cell Mol Life Sci. 2004; 61(9):1082-94.

Brauer AU, Nitsch R, Savaskan NE. Identification of macrophage/microglia activation factor (MAF) associated with late endosomes/lysosomes in microglial cells. FEBS Lett. 2004;563(1-3):41-8.

Schweizer U, Brauer AU, Kohrle J, Nitsch R, Savaskan NE. Selenium and brain function: a poorly recognized liaison. Brain Res Brain Res Rev. 2004; 45(3):164-78.

Schweizer U, Schomburg L, Savaskan NE. The neurobiology of selenium: lessons from transgenic mice. J Nutr. 2004 Apr;134(4):707-10.

Brauer AU, Savaskan NE. Molecular actions of selenium in the brain: neuroprotective mechanisms of an essential trace element. Rev Neurosci. 2004;15(1):19-32.

Savaskan NE, Bräuer AU,Nitsch R. Molecular cloning and expression regulation of PRG-3, a novel member of the plasticity-related gene family. Eur J Neurosci 2004 Jan; 19(1): 212-220.

Bräuer AU, Savaskan NE*, Kühn H, Prehn S, Ninnemann O, Nitsch R. The novel phospholipid PRG-1 is involved in axon growth and regenerative sprouting. Nature Neurosci 2003; 6(6):572-8.

Eyupoglu IY, Savaskan NE*, Brauer AU, Nitsch R, Heimrich B. Identification of neuronal cell death in a model of degeneration in the hippocampus. Brain Res Brain Res Protoc. 2003;11(1):1-8.

Meier S, Bräuer AU, Heimrich B, Schwab ME, Nitsch R, Savaskan NE. Molecular analysis of Nogo genes in the hippocampus. FASEB J 2003 Jun;17(9):1153-5.

Savaskan NE, Brauer AU, Kühbacher M, Eyüpoglu IY, Kyriakopoulos A, Ninnemann O, Behne D, Nitsch R. Selenium deficiency increases the susceptibility to excitatory cell death. FASEB J 2003, 17(9):1153-1155.

Savaskan NE, Alvarez-Bolado G, Glumm R, Nitsch R, Skutella T & Heimrich B. Impaired postnatal development of hippocampal neurons and axon projections in the Emx2P-/- mutants. J Neurochem 2002, ;83(5):1196-207.

Bräuer AU, Savaskan NE*, Kole MH, Plaschke M, Monteggia LM, Nestler EJ, Simburger E, Deisz RA, Ninnemann O, Nitsch R. Molecular and functional analysis of hyperpolarization-activated pacemaker channels in the hippocampus after entorhinal cortex lesion. FASEB J 2001, 15: 2689-2701.

Savaskan NE & Nitsch R. Molecules involved in reactive sprouting in the hippocampus following perforant path lesion. Rev Neuroscie. 2001, 12: 195-215.

Brauer AU, Savaskan NE*, Plaschke M, Ninnemann O, Nitsch R. Perforant path lesion induces upregulation of stathmin mRNA, but not SCG10 mRNA, in the adult rat hippocampus. Neurosci. 2001, 102 (3): 515-526.

Brauer AU, Savaskan NE*, Plaschke M, Prehn S, Ninnemann O, Nitsch R. The Ig-molecule Kilon shows a differential expression pattern to LAMP in the developing and adult hippocampus. Hippocampus. 2000, 10: 632-644.

Savaskan NE, Eyupoglu IY, Brauer AU, Plaschke M, Ninnemann O, Nitsch R, Skutella T. Entorhinal cortex lesion studied with the novel dye fluoro-jade. Brain Res. 2000, 2;864(1):44-51.

Savaskan NE, Skutella T, Brauer AU, Plaschke M, Ninnemann O, Nitsch R. Outgrowth-promoting molecules in the adult hippocampus after perforant path lesion. Eur J Neurosci. 2000;12(3):1024-32.

Steup A, Lohrum M, Hamscho N, Savaskan NE, Ninnemann O, Nitsch R, Fujisawa H, Puschel AW, Skutella T. Sema3C and netrin-1 differentially affect axon growth in the hippocampal formation. Mol Cell Neurosci. 2000;15(2):141-55.

Steup A, Ninnemann O, Savaskan NE, Nitsch R, Puschel AW, Skutella T. Semaphorin D acts as a repulsive factor for entorhinal and hippocampal neurons. Eur J Neurosci. 1999; 11(2):729-34.

Stein E, Savaskan NE*, Ninnemann O, Nitsch R, Zhou R, Skutella T. A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting. J Neurosci. 1999 Oct 15;19(20):8885-93.

Skutella T, Savaskan NE*, Ninnemann O, Nitsch R. Target- and maturation-specific membrane-associated molecules determine the ingrowth of entorhinal fibers into the hippocampus. Dev Biol. 1999 Jul 15;211(2):277-92.

Savaskan NE, Plaschke M, Ninnemann O, Spillmann AA, Schwab ME, Nitsch R, Skutella T. Myelin does not influence the choice behaviour of entorhinal axons but strongly inhibits their outgrowth length in vitro. Eur J Neurosci. 1999 Jan;11(1):316-26.

Editorial comments

Savaskan, N E.; Eyupoglu, Ilker Y. Increased xCT Expression Correlates With Tumor Invasion and Outcome in Patients With Glioblastomas COMMENT. NEUROSURGERY 2013; 72 (1): 41-41.

Book chapters

Hock SW, Fan Z, Eyüpoglu IY, and Savaskan NE. Brain Tumor–Induced Angiogenesis: Approaches and Bioassays, in Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications, Dr. Terry Lichtor (Ed.), ISBN: 978-953-51-0989-1, InTech, DOI: 10.5772/53182. Available from: http://www.intechopen.com/books/evolution-of-the-molecular-biology-of-brain-tumors-and-the-therapeutic-implications/brain-tumor-induced-angiogenesis-approaches-and-bioassays. 2012

Savaskan NE, Hore N, Eyüpoglu IY Selenium and Selenoproteins in Neuronal Cell Death and Protection. In Metal Ions in Stroke. Editors: Yang V Li, John H. Zhang. Springer 2011.

Community Service papers

Savaskan, N E., & Eyupoglu, IY. Aneurysma Studien. Dtsch Arztebl 2015; 112(29-30): A-1293 / B-1083 / C-1055. https://www.aerzteblatt.de/pdf/112/29/a1293.pdf?ts=14.07.2015..

https://www.aerzteblatt.de/pdf/112/29/a1293.pdf?ts=14.07.2015+12%3A38%3A00

Savaskan, N E., & Eyupoglu, IY &. Friedlein Grading: neues prognostisches Klassifikationssystem. Ärztliches Journal Onkologie 4, 2015, 4. Ausgabe 2014: 26 – 28.

Eyupoglu, IY & Savaskan, N E. Der Hydrocephalus. Forum Sanitas, 4. Ausgabe 2014: 23 – 25.

Eyupoglu, IY & Savaskan, N E. Neue Möglichkeiten in der Behandlung von Hirntumoren. Forum Sanitas, 4. Ausgabe 2013: 27 – 29.

Savaskan, N E. Fachbeirat zu: Hirntumoren und Tumoren des Zentralnervensystems. Krebsliga Schweiz, 1. Ausgabe 2009.

Savaskan, N E. Wissenschaftliches Publizieren – Umstritten, aber etabliert – der Impact Factor: Tücken. Dtsch Arztebl 2002; 99(51-52): A-3455 / B-2911 / C-2711.

https://www.aerzteblatt.de/treffer?mode=s&wo=17&typ=16&aid=34957&s=savaskan

http://orcid.org/0000-0003-1348-094X